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Your Position: Start > Serpin F1

Serpin F1

Brief Information

Name:Pigment epithelium-derived factor
Target Synonym:Cell proliferation-inducing gene 35 protein,EPC-1,Serpin Family F Member 1,Proliferation-Inducing Protein 35,OI12,Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1,PIG35,Serine (Or Cysteine) Proteinase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1,OI6,Testis Tissue Sperm-Binding Protein Li 70n,SERPINF1,Serpin F1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

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SE1-H5221 Human Human Serpin F1 / PEDF Protein, His Tag
SE1-H5221-structure
SE1-H5221-sds
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Synonym Name

SERPINF1,Serpin F1,PEDF,PIG35,EPC-1

Background

erpin F1 (SERPINF1) is also known as Pigment epithelium-derived factor (PEDF), Cell proliferation-inducing gene 35 protein (PIG35). Serpin F1 belongs to the serpin family. Serpin F1 is expressed in quiescent cells. PEDF has a variety of functions including antiangiogenic, antitumorigenic, and neurotrophic properties. Endothelial cell migration is inhibited by SERPINF1/ PEDF. PEDF / SERPINF1 suppresses retinal neovascularization and endothelial cell proliferation. PEDF is also responsible for apoptosis of endothelial cells either through the p38 MAPK pathway or through the FAS/FASL pathway. PEDF also displays neurotrophic functions.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BRM-421 BRM-421 Phase 3 Clinical Brim Biotechnology Co Ltd Dry Eye Syndromes; Xerophthalmia Details
DVC1-0401 DVC1-0401 Phase 2 Clinical Kyushu University, Id Pharma Retinitis Pigmentosa Details
BRM-421 BRM-421 Phase 3 Clinical Brim Biotechnology Co Ltd Dry Eye Syndromes; Xerophthalmia Details
DVC1-0401 DVC1-0401 Phase 2 Clinical Kyushu University, Id Pharma Retinitis Pigmentosa Details

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